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Exploring the Different Routes of Administration for Ketamine and Their Dissociation Experiences

Ketamine is a dissociative anesthetic commonly used for its sedative and pain-relieving effects. It can be administered through various routes with unique characteristics and dissociation experiences. Let’s explore the different routes of administration of ketamine and their dissociation experiences.


· Intravenous (IV) Administration

o IV administration is the most common route of ketamine administration. It involved injecting ketamine directly into the bloodstream, allowing it to take effect rapidly within seconds. The dissociation experience with IV experience is intense and profound, with users often experiencing a complete detachment from their body and surroundings. The dissociation can last up to an hour or more, depending on the dosage.


· Intramuscular (IM) Administration

o IM administration involves injecting ketamine into the muscle tissue, which takes a few minutes to take effect. The dissociation experience with IM ketamine is similar to IV administration, but the onset of dissociation is slower and less intense. The dissociation state lasts for a shorter duration than IV administration, usually around 30-45 minutes.


· Intranasal (IN) Administration

o IN administration involves administering ketamine through the nasal membrane. The dissociation experience with IN ketamine is less intense than with IV or IM administration, and the onset of dissociation is slower, taking around 5-10 minutes to take effect. The dissociative state usually lasts up to an hour, depending on the dosage.


· Sublingual Administration

o Sublingual administration involves placing a small amount of ketamine under the tongue and allowing it to dissolve slowly. The dissociation experience associated with sublingual ketamine has a slower onset, and the dissociative state usually lasts for up to an hour or more, depending on the dosage.


Ketamine can be administered through various routes, each with its unique dissociation experience. Outside of the route of administration, the dosage has a lot to do with the dissociative experience that each individual will experience. It is important to note that ketamine is a powerful drug and should only be administered under the supervision of a medical professional.

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